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Spicer JD, Shewale J, Correa AM, Heymach JV, Antonoff MB, Hofstetter W, Mehran R, Roth J, Rice D, Sepesi B, Vaporciyan AA, William W, Walsh G, Swisher S

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albicans exhibits remarkable intraspecific strain heterogeneity, which is driven by genetic variations including aneuploidy, loss of heterozygosity, copy number variations and single nucleotide polymorphisms, as well as epigenetic phenotypic switching and niche-specific adaptive regulation, and this heterogeneity directly leads to significant differences in pathogenicity, biofilm formation ability and drug responsiveness among different strains (Hirakawa et al., 2015)

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Moreover, treatment of mental diseases usually demands chronic, often combined, therapy